Formula: C10H16O4. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: (1S,3R)-1,2,2-Trimethylcyclopentane-1,3-dicarboxylic acid, is researched, Molecular C10H16O4, CAS is 560-09-8, about Synthesis, characterisation and biological activity of chiral platinum(II) complexes. Author is Jaramillo, David; Buck, Damian P.; Collins, J. Grant; Fenton, Ronald R.; Stootman, Frank H.; Wheate, Nial J.; Aldrich-Wright, Janice R..
Four Pt(II) complexes of 1,10-phenanthroline (phen) and 3,4,7,8-tetramethyl-1,10-phenanthroline (3,4,7,8-Me4phen), with the chiral ancillary ligands (1R,3S)- and (1S,3R)-1,3-diamino-1,2,2-trimethylcyclopentane (R,S-tmcp and S,R-tmcp, resp.) were synthesized and their biol. activity quantified using an in vitro cytotoxicity assay against the L1210 murine leukemia cell line. [Pt(R,S-tmcp)(3,4,7,8-Me4phen)]Cl2 and [Pt(S,R-tmcp)(3,4,7,8-Me4phen)]Cl2 showed an increase in biol. activity over their nonmethylated complexes, [Pt(R,S-tmcp)(phen)]Cl2 and [Pt(S,R-tmcp)(phen)]Cl2. Some chiral discrimination was observed in the in vitro cytotoxicity experiments with the complexes having (S,R) configuration showing higher biol. activity in L1210 cells. Titrations of the metal complexes into ct-DNA and observation of the changes induced in the CD spectra were used to determine the binding constants The binding of these metal complexes to the hexamer d(GTCGAC)2 was studied using two-dimensional 1H NMR spectroscopy. The addition of metal complexes to the hexamer produced upfield shifts of the metal complex of selected resonances, characteristic of intercalation for [Pt(tmcp)(phen)]Cl2, whereas the [Pt(tmcp)(3,4,7,8-Me4phen)]Cl2 complexes only partially intercalate and in a side-on fashion. Through the observation of NOE cross-peaks, two-dimensional NMR experiments provided some insight into the site and groove preferences of these complexes when binding to DNA. Here, the authors report the biol. activity of Pt(II) complexes containing an intercalator and a chiral diamine, which influences the degree to which the complexes can interact with DNA.
Although many compounds look similar to this compound(560-09-8)Formula: C10H16O4, numerous studies have shown that this compound(SMILES:CC1(C)[C@@H](CC[C@]1(C)C(O)=O)C(O)=O), has unique advantages. If you want to know more about similar compounds, you can read my other articles.
Reference:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com