Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Journal of Medicinal Chemistry called Potent Benzimidazole Sulfonamide Protein Tyrosine Phosphatase 1B Inhibitors Containing the Heterocyclic (S)-Isothiazolidinone Phosphotyrosine Mimetic, Author is Combs, Andrew P.; Zhu, Wenyu; Crawley, Matthew L.; Glass, Brian; Polam, Padmaja; Sparks, Richard B.; Modi, Dilip; Takvorian, Amy; McLaughlin, Erin; Yue, Eddy W.; Wasserman, Zelda; Bower, Michael; Wei, Min; Rupar, Mark; Ala, Paul J.; Reid, Brian M.; Ellis, Dawn; Gonneville, Lucie; Emm, Thomas; Taylor, Nancy; Yeleswaram, Swamy; Li, Yanlong; Wynn, Richard; Burn, Timothy C.; Hollis, Gregory; Liu, Phillip C. C.; Metcalf, Brian, which mentions a compound: 119639-24-6, SMILESS is O=C(C=C1)N(C(C)(C)C)S1(=O)=O, Molecular C7H11NO3S, Recommanded Product: 2-(tert-Butyl)isothiazol-3(2H)-one 1,1-dioxide.
Potent nonpeptidic benzimidazole sulfonamide inhibitors of protein tyrosine phosphatase 1B (PTP1B) were derived from the optimization of a tripeptide containing the novel (S)-isothiazolidinone ((S)-IZD) phosphotyrosine (pTyr) mimetic. An x-ray cocrystal structure of inhibitor 46/PTP1B at 1.8 Å resolution demonstrated that the benzimidazole sulfonamides form a bidentate H bond to Asp-48 as designed, although the aryl group of the sulfonamide unexpectedly interacts intramolecularly in a pi-stacking manner with the benzimidazole. The ortho substitution to the (S)-IZD on the aryl ring afforded low nanomolar enzyme inhibitors of PTP1B that also displayed low caco-2 permeability and cellular activity in an insulin receptor (IR) phosphorylation assay and an Akt phosphorylation assay. The design, synthesis, and SAR of this novel series of benzimidazole sulfonamide containing (S)-IZD inhibitors of PTP1B are presented herein.
In some applications, this compound(119639-24-6)Recommanded Product: 2-(tert-Butyl)isothiazol-3(2H)-one 1,1-dioxide is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.
Reference:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com