The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 2-(tert-Butyl)isothiazol-3(2H)-one 1,1-dioxide( cas:119639-24-6 ) is researched.SDS of cas: 119639-24-6.Waldner, Adrian published the article 《[4+2] Cycloaddition of α,β-unsaturated hydrazones. 3. Isothiazolo[4,5-b]pyridin-3(2H)-one 1,1-dioxides (4-azasaccharin derivatives)》 about this compound( cas:119639-24-6 ) in Helvetica Chimica Acta. Keywords: unsaturated hydrazone cycloaddition isothiazolone dioxide; azabutadiene cycloaddition isothiazolone; solvent effect cycloaddition isothiazolone dioxide azabutadiene; isothiazolopyridinone dioxide; azasaccharin derivative. Let’s learn more about this compound (cas:119639-24-6).
The [4 + 2] cycloaddition of α,β-unsaturated hydrazones, Me2NN:CHCR:CHR1 (R = Me, Et, CHMe2, R1 = H; R = R1 = Me), (1-azabuta-1,3-dienes) with isothiazol-3(2H)-one 1,1-dioxide derivatives I (R2 = H, CMe3, Me3CCH2CMe2, 4-ClC6H4, PhCH2, 4-MeOC6H4CH2) affords, depending on the solvent used, picolinamides II or III, and 4-azasaccharin derivatives IV or V. The course of the reaction is mainly influenced by the substituent R2 of the dienophile I.
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Reference:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com