The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 2-(tert-Butyl)isothiazol-3(2H)-one 1,1-dioxide, is researched, Molecular C7H11NO3S, CAS is 119639-24-6, about Tilcotil studies. [3+2]Additions with isothiazol-3(2H)-one 1,1-dioxide, the main research direction is isothiazolone dioxide regiospecific cycloaddition; tenoxicam analog; piroxicam analog; safety pyrazoloisothiazolone dioxide preparation.Application In Synthesis of 2-(tert-Butyl)isothiazol-3(2H)-one 1,1-dioxide.
Derivatives of isothiazol-3(2H)-one 1,1-dioxide (I) react regiospecifically with 1,3-dipolar agents. The main regiocontrolling factor is the C:O group of the dipolarophile. The topol. of the adducts is also in general agreement with predictions based on perturbation theory. Several adducts can be aromatized to heterocyclic equivalents of saccharin, and can then be elaborated into structural analogs of tenoxicam (Tilcotil) and piroxicam (Feldene).
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Reference:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com