In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Quantum Chemistry, NMR Spectroscopy, and Single-Crystal Diffractometry Methods in the Analysis of Protonation Pathways of 2-Amino-4-benzylsulfanyl-6-methylpyrimidines, published in 2019-01-31, which mentions a compound: 6307-44-4, mainly applied to aminomethyl pyrimidinethione benzyl chloride protonation mechanism NMR chem shift, Application In Synthesis of 2-Amino-6-methylpyrimidine-4-thiol.
Protonation pathways of 2-amino-4-benzylsulfanyl-6-methylpyrimidines have been investigated by means of semiempirical PM3 quantum-chem. simulation, 13C NMR spectroscopy, and single-crystal diffractometry methods. In the gas phase and in the bipolar aprotic solvent, the protonation involves the N1 atom. The protonation in the crystalline state is characterized by the formation of a branched system of H-bonds, involving the protons of the amino group besides the mentioned nitrogen atom.
If you want to learn more about this compound(2-Amino-6-methylpyrimidine-4-thiol)Application In Synthesis of 2-Amino-6-methylpyrimidine-4-thiol, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(6307-44-4).
Reference:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com