Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Bioorganic & Medicinal Chemistry Letters called Discovery of potent, balanced and orally active dual NK1/NK3 receptor ligands, Author is Peters, Jens-Uwe; Hoffmann, Torsten; Schnider, Patrick; Stadler, Heinz; Koblet, Andreas; Alker, Andre; Poli, Sonia Maria; Ballard, Theresa M.; Spooren, Will; Steward, Lucinda; Sleight, Andrew J., which mentions a compound: 400777-00-6, SMILESS is O=C(OC(C)(C)C)NC1=C(I)C=C(Cl)N=C1, Molecular C10H12ClIN2O2, Synthetic Route of C10H12ClIN2O2.
During a program directed at selective NK1 receptor antagonists, we serendipitously discovered an NK1 receptor ligand with addnl. affinity for the NK3 receptor. Recognising an opportunity for a drug discovery program aiming for dual NK1/NK3 receptor antagonists, we prepared a series of analogs from a novel, versatile building block. From this series emerged compounds with high and balanced affinities for the NK1 and the NK3 receptors. Typical representatives of this series were active in the gerbil foot tapping assay after oral administration.
If you want to learn more about this compound(tert-Butyl (6-chloro-4-iodopyridin-3-yl)carbamate)Synthetic Route of C10H12ClIN2O2, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(400777-00-6).
Reference:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com