An article Structure-Activity Relationship of Indolylkojylmethane Based on Antiproliferative Activity against Breast Cancer WOS:000587726400011 published article about KOJIC ACID-DERIVATIVES in [Koli, Papita; Sharma, Deepak K.] Banaras Hindu Univ, Indian Inst Technol, Dept Pharmaceut Engn & Technol, Varanasi 221005, Uttar Pradesh, India; [Reena] Overseas Healthcare Pvt Ltd, Phillaur, Punjab, India; [Mehra, Rukmankesh] Indian Inst Technol Bhilai, Dept Chem, Raipur 492015, Chhattisgarh, India in 2020.0, Cited 20.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7. Recommanded Product: 2,5-Dimethoxybenzaldehyde
A series of indolylkojylmethane (IKM) derivatives (1-23) was synthesized using a multicomponent one-pot reaction under solvent-free condition using a heterogeneous catalyst. The synthesized compounds were screened against breast cancer cell lines MDA-MB-231, MCF7, and T47D. The structure-activity relationship revealed that IKM synthesized from aliphatic aldehydes (9-11) were active against all three cell lines and showed IC50 value of 0.15 mu M-3.93 mu M. IKM synthesized from aromatic aldehydes having electron-donating group (1, 5, and 6) specifically inhibited the proliferation of the MDA-MB-231 cell line. The effect of various substituted indoles (12-17) was also studied and observed that compound 14 synthesized from 5-cyanoindole, specifically inhibited T47D cell line proliferation. Replacing indole (1) with nucleophiles (18-23) in IKM decreased the antiproliferative activity. Compound 10 synthesized from kojic acid, indole and octanal was found to be most potent with IC50 values of 0.21, 0.15, and 3.45 mu M against MDA-MB-231, MCF7, and T47D, respectively.
Recommanded Product: 2,5-Dimethoxybenzaldehyde. Welcome to talk about 93-02-7, If you have any questions, you can contact Koli, P; Reena; Mehra, R; Sharma, DK or send Email.
Reference:
Isothiazole – Wikipedia,
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