Application In Synthesis of Benzoic anhydride. Recently I am researching about BETA-ENAMINO ESTERS; ENANTIOSELECTIVE REDUCTION; ASYMMETRIC HYDROSILYLATION; RATIONAL DESIGN; AMINES; PERSPECTIVE; DERIVATIVES; SELECTIVITY; AMIDATION; LIGANDS, Saw an article supported by the Regione LombardiaRegione Lombardia; Universita degli Studi di Milano (grant PSR 2017); Universita degli Studi di Milano. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Massolo, E; Pirola, M; Puglisi, A; Rossi, S; Benaglia, M. The CAS is 93-97-0. Through research, I have a further understanding and discovery of Benzoic anhydride
A two-step one pot, experimentally simple protocol, based on readily available and inexpensive reagents allowed the conversion of nitro-arenes directly to N-aryl amides. A metal-free reduction of the nitro group, mediated by trichlorosilane, followed by the addition of an anhydride afforded the corresponding N-aryl carboxyamide, that was isolated after a simple aqueous work up in good-excellent yields. When the methodology was applied to the reaction with gamma-butyrolactone, the desired N-aryl butanamide derivative was obtained, featuring a chlorine atom at the gamma-position, a functionalized handle that can be used for further synthetic manipulation of the reaction product. Such an intermediate has already been employed as a key advanced precursor of pharmaceutically active compounds.
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Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com