COA of Formula: C9H10O3. Authors Ximenis, M; Mulet, J; Sala, S; Sala, F; Criado, M; Gonzalez-Muniz, R; de Vega, MJP in MDPI published article about in [Ximenis, Marta; Gonzalez-Muniz, Rosario; Perez de Vega, Maria Jesus] CSIC, IQM, Inst Quim Med, Juan Cierva 3, Madrid 28006, Spain; [Mulet, Jose; Sala, Salvador; Sala, Francisco; Criado, Manuel] Univ Miguel Hernandez, CSIC, Inst Neurociencias, Sant Joan dAlacant 03050, Spain in 2021.0, Cited 65.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7
The alpha 7 nicotinic acetylcholine receptor (alpha 7 nAChR) is a ligand-gated ion channel that is involved in cognition disorders, schizophrenia, pain, and inflammation. Allosteric modulation of this receptor might be advantageous to reduce the toxicity in comparison with full agonists. Our previous results obtained with some hydroxy-chalcones, which were identified as positive allosteric modulators (PAMs) of alpha 7 nAChR, prompted us to evaluate the potential of some structurally related naturally occurring flavonoids and curcuminoids and some synthetic curcumin analogues, with the aim of identifying new allosteric modulators of the alpha 7 nAChR. Biological evaluation showed that phloretin, demethoxycurcumin, and bis-demethoxicurcuming behave as PAMs of alpha 7 nAChR. In addition, some new curcumin derivatives were able to enhance the signal evoked by ACh; the activity values found for the tetrahydrocurcuminoid analog 23 were especially promising.
Welcome to talk about 93-02-7, If you have any questions, you can contact Ximenis, M; Mulet, J; Sala, S; Sala, F; Criado, M; Gonzalez-Muniz, R; de Vega, MJP or send Email.. COA of Formula: C9H10O3
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