Recommanded Product: 3-Methylbenzoic acid. Wang, SP; Cheung, CW; Ma, JA in [Cheung, Chi Wai; Ma, Jun-An] Tianjin Univ, Tianjin Key Lab Mol Optoelect Sci, Dept Chem, Tianjin 300072, Peoples R China; Tianjin Univ, Tianjin Collaborat Innovat Ctr Chem Sci & Engn, Tianjin 300072, Peoples R China; Joint Sch NUS & TJU, Int Campus Tianjin Univ, Fuzhou 350207, Fujian, Peoples R China published Direct Amidation of Carboxylic Acids with Nitroarenes in 2019, Cited 87. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7.
N-Aryl amides are an important class of compounds in pharmaceutical and agrochemical chemistry. Rapid and low-cost synthesis of N-aryl amides remains in high demand. Herein, we disclose an operationally simple process to access N-aryl amides directly from readily available nitroarenes and carboxylic acids as coupling substrates. This method involves the in situ activation of carboxylic acids to acyloxyphosphonium salt for one-pot amidation, without the need for isolation of the corresponding synthetic intermediates. Furthermore, the ease of preparation and workup allow the quick and efficient synthesis of a wide range of N-aryl amides, including several amide-based druglike and agrochemical molecules.
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Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com