With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7716-66-7,3-Chlorobenzo[d]isothiazole,as a common compound, the synthetic route is as follows.
Ethylenediamine (45 mL) was heated to 80 0C. A room temperature solution of 3-chlorobenzo[d]isothiazole (12g, 70.7 mmol) in ethylenediamine (5 mL) was added to the heated ethylenediamine dropwise. The resulting solution was heated at 80 0C for 3 h. The reaction mixture was cooled to room temperature and water (75 mL) was added. The aqueous mixture was extracted with ethyl acetate twice and the ethyl acetate layers were separated. The combined organic layers were dried over anhydrous sodium sulfate, filtered and the filtrate concentrated under reduced pressure to yield N1-(benzo[d]isothiazol-3-yl)ethane-l,2-diamine as a light yellow solid (8 g). 1H-NMR (300 MHz, CDCl3): 7.79-7.64 (m, 2H), 7.52 (t, IH), 7.34 (t, IH), 5.60 (broad s, IH), 3.62 (t, 2H), 3.08 ppm (t, 2H).
7716-66-7 3-Chlorobenzo[d]isothiazole 598190, aisothiazole compound, is more and more widely used in various.
Reference£º
Patent; RIGEL PHARMACEUTICALS, INC.; WO2006/91858; (2006); A1;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com