As a common heterocyclic compound, it belong isothiazole compound,3,4-Dichloroisothiazole-5-carboxylic acid,18480-53-0,Molecular formula: C4HCl2NO2S,mainly used in chemical industry, its synthesis route is as follows.,18480-53-0
After 10 g of 50 mmol of 3,4-dichloro-isothiazole carboxylic acid II was added to 100 ml flask was added 30 ml of thionylchloride, refluxed for 5 hours, thionyl chloride was distilled off at atmospheric pressure, the residue was water pump vacuumdistillation at 100-110 degrees C compound fraction collected between 10.6 g yellow solid 3,4-dichloro-isothiazole carboxylicacid chloride III, a yield of 96.3percent, 3,4-dichloro-isothiazole carboxylic acid chloride III prepared a pro rata amount of expanded orreduced, the volume of the reaction vessel according to the corresponding scaled up or down, a commercially availablecompound II has the same effect.
With the synthetic route has been constantly updated, we look forward to future research findings about 3,4-Dichloroisothiazole-5-carboxylic acid,belong isothiazole compound
Reference£º
Patent; Jiangxi Tianren Ecology Co., Ltd.; Nankai University; Chen, Xiaoyan; Liu, Xiping; Fan, Zhijin; Liang, Xiaowen; Li, Yuedong; Mao, Wutao; Li, Juanjuan; Wang, Dun; Wang, Shuhua; Zhou, Lifeng; Ji, Xiaotian; HUA, XUEWEN; (23 pag.)CN102942565; (2016); B;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com