An article Synthesis of Biaryls via Decarbonylative Palladium-Catalyzed Suzuki-Miyaura Cross-Coupling of Carboxylic Acids WOS:000488278300064 published article about C-O ACTIVATION; DENSITY FUNCTIONALS; ORGANIC-SYNTHESIS; ARYL; HETEROARYL; ARENES; COMPLEXES; AMIDES; TRANSMETALATION; THERMOCHEMISTRY in [Szostak, Michal] Shaanxi Univ Sci & Technol, Coll Chem & Chem Engn, Minist Educ, Xian 710021, Shaanxi, Peoples R China; [Szostak, Michal] Shaanxi Univ Sci & Technol, Key Lab Auxiliary Chem & Technol Chem Ind, Minist Educ, Xian 710021, Shaanxi, Peoples R China; [Liu, Chengwei; Szostak, Michal] Rutgers State Univ, Dept Chem, 73 Warren St, Newark, NJ 07102 USA; [Ji, Chong-Lei; Qin, Zhi-Xin; Hong, Xin] Zhejiang Univ, Dept Chem, Hangzhou 310027, Zhejiang, Peoples R China in 2019, Cited 101. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7. Computed Properties of C8H8O2
The biaryl motif is a building block in many drugs, agrochemicals, and materials, and as such it is highly desirable as a synthesis target. The state-of-the-art process for biaryl synthesis from ubiquitous carboxylic acids is decarboxylative cross-coupling involving loss of carbon dioxide (CO2). However, the scope of these methods is severely limited, mainly due to specific substitution required to promote decarboxylation. The present report implements a decarbonylative version with loss of carbon monoxide (CO) that enables to directly engage carboxylic acids in a Suzuki-Miyaura cross-coupling to produce biaryls as a general method with high cross-coupling selectivity using a well-defined Pd(0)/(II) catalytic cycle. This protocol shows a remarkably broad scope (>80 examples) and is performed in the absence of exogenous inorganic bases. In a broader context, the approach shows promise for routine applications in the synthesis of biaryls by carefully controlled decarbonylation of prevalent carboxylic acids.
Computed Properties of C8H8O2. Welcome to talk about 99-04-7, If you have any questions, you can contact Liu, CW; Ji, CL; Qin, ZX; Hong, X; Szostak, M or send Email.
Reference:
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