Machine Learning in Chemistry about 2,5-Dimethoxybenzaldehyde

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Recommanded Product: 93-02-7. I found the field of Chemistry very interesting. Saw the article An Efficient and Transition Metal-Free Base-Promoted Multi-Component Synthesis of Aza-Fused Polysubstituted Pyrido[2 ‘,3 ‘:3,4]Pyrazolo[1,5-a]Pyrimidine Derivatives published in 2020.0, Reprint Addresses Jeong, YT (corresponding author), Pukyong Natl Univ, Dept Image Sci & Engn, Busan 608737, South Korea.. The CAS is 93-02-7. Through research, I have a further understanding and discovery of 2,5-Dimethoxybenzaldehyde.

An efficient and concise practical protocol for the synthesis of novel aza-fused polysubstituted pyrido[2 ‘,3 ‘:3,4]pyrazolo[1,5-a]pyrimidine derivatives from a readily available aromatic aldehyde, acetophenone and 1H-pyrazolo[3,4-b]pyridin-3-amine in presence of Ba(OH)(2), under transition metal-free conditions, has been established. This transformation presumably occurs through a sequential Aldol reaction, imine-formation, intramolecularN-cyclization, auto-oxidation sequence of reactions. This protocol, which includes the formation of new C-C and C-N bonds, features a wide substrate scope with a broad range of functional group tolerance.

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Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com