Recently I am researching about CATALYZED HECK; ALKYNYLATION, Saw an article supported by the NIHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) – USA [1R35GM133326]; NSFNational Science Foundation (NSF) [CAREER CHE-1650766]; NSF-MRINational Science Foundation (NSF)NSF – Office of the Director (OD) [CHE-1229030]; Rutgers Graduate School. SDS of cas: 99-04-7. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Liu, CW; Szostak, M. The CAS is 99-04-7. Through research, I have a further understanding and discovery of 3-Methylbenzoic acid
Decarbonylative Sonogashira cross-coupling of carboxylic acids by palladium catalysis is presented. The carboxylic acid is activated in situ by the formation of a mixed anhydride and further decarbonylates using the Pd(OAc)(2)/Xantphos system to provide an aryl-Pd intermediate, which is intercepted by alkynes to access the traditional Pd(0)/(II) cycle using carboxylic acids as ubiquitous and orthogonal electrophilic cross-coupling partners. The methodology efficiently constructs new C(sp(2))-C(sp) bonds and can be applied to the derivatization of pharmaceuticals. Mechanistic studies give support to decarbonylation preceding transmetalation in this process.
SDS of cas: 99-04-7. Bye, fridends, I hope you can learn more about C8H8O2, If you have any questions, you can browse other blog as well. See you lster.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com