3-Piperazinobenzisothiazole hydrochloride, cas is 87691-88-1, it is a common heterocyclic compound, the isothiazole compound, its synthesis route is as follows.,87691-88-1
EXAMPLE 1; N-(5-r2-(4-BENZOrD1ISOTHIAZOL-3-YL-PIPERAZIN-1-YL)-ETHYU-15 INDAN-2-YU-2.2.2-TRIFLUORO-ACET AMIDE; N-[5-(2-Chloro-ethyl)-indan-2-yl]-2,2,2-trifluoro-acetamide (S.OOg, 10.28mmol), 3-piperazin-1-yl-benzo[d]isothiazole hydrochloride (5.26g, 20.57mmol) and sodium carbonate (2.18g, 20.57 mmol) in H2O (20mL) wassubjected to 175 C for 10 min. under microwave assistance using a GEM20 MARS-5 microwave. The reaction was diluted with H2O (50 mL) andEtOAc (100 ml). The layers were separated and the organics washedwith 4N HCI (2x 25 mL). The aqueous layer was made basic andextracted with CH2CI2 (3×50 mL). The organics were dried (MgSO4), andconcentrated to a solid residue. The residue was subjected to25 chromatography (3% MeOH/CH2CI2). N-{5-[2-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-ethyl]-indan-2-yl}-2,2,2-trifluoro-acetamide (3.20g),wasisolated in 100% purity (at) 254 nm; LCMS (APCI): 475 [M+H]+. 1H NMR(400 MHz, CDCI3) 5 7.90 (d, J=8.2Hz, 1H), 7.80 (d, J= 8.2Hz, 1H), 7.46 (t,J = 7.4HZ, 1 H), 7.34 (t, J= 7.4Hz, 1 H), 7.17 (d, J= 7.4Hz, 1 H), 7.12 (s, 1 H),30 7.08 (d, J= 7.4Hz, 1 H), 6.46 (bs, 1 H), 4.82-4.71 (m, 1 H), 3.63-3.55 (m,4H), 3.40-3.29 (m, 2H), 2.90-2.80 (m, 4H), 2.79-2.72 (m, 4H), 2.71-2.65(m, 2H).
87691-88-1 is used more and more widely, we look forward to future research findings about 3-Piperazinobenzisothiazole hydrochloride
Reference£º
Patent; WARNER-LAMBERT COMPANY LLC?; WO2005/56540; (2005); A1;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com