An article Novel Pyrazolo[3,4-d]pyrimidine-Containing Amide Derivatives: Synthesis, Molecular Docking, In Vitro and In Vivo Antidiabetic Activity WOS:000490895800027 published article about BIOLOGICAL EVALUATION; DIABETES-MELLITUS; INHIBITORS; ANTIBACTERIAL; PYRIMIDINE; DIET in [Reddy, Bijivemula N.; Pathak, Madhvesh] Vellore Inst Technol, Sch Adv Sci, Vellore 632014, Tamil Nadu, India; [Ruddarraju, Radhakrishnam Raju] Factory Plot 79-B&C, Patancheru 502307, Andhra Pradesh, India; [Ruddarraju, Radhakrishnam Raju] Jawaharlal Nehru Technol Univ, Hyderabad 500085, Telangana, India; [Kiran, Gangarapu] Anurag Grp Inst, Dept Pharmaceut Anal & Chem, Sch Pharm, Ghatkesar M, Telangana, India; [Reddy, Anreddy Rama Narsimha] Jyothishmathi Inst Pharmaceut Sci, Dept Pharmacol, Karimnagar 505481, Telangana, India in 2019, Cited 45. Recommanded Product: 99-04-7. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7
A new series of Pyrazolo[3,4-d]pyrimidine containing amide derivatives (8 a-l) were designed, synthesized, and evaluated for their in vitro alpha-amylase inhibitory activity. The IC50 values of the target compounds ranged from 1.60 +/- 0.48 to 2.04 +/- 1.20 mu M as compared to the standard acarbose 1.73 +/- 0.05 mu M. All the Pyrazolo[3,4-d]pyrimidine amide derivatives displayed good inhibitory activities, while seven analogs (8 d, 8 f, 8 g, 8 h, 8 i, 8 j and 8 k) exhibited more or less equipotent activity with IC50 values 1.77 +/- 2.84, 1.65 +/- 0.45, 1.66 +/- 2.24, 1.73 +/- 0.37, 1.60 +/- 0.48, 1.75 +/- 0.36 and 1.64 +/- 0.03 mu M respectively. Further, the most potent alpha-amylase inhibitors 8 d and 8 k were also screened for their in vivo antidiabetic activity against alloxan induced diabetic rat model at the dose of 25 and 50 mg/kg. Oral administration of these tested compounds significantly reduced the fasting blood glucose levels in dose dependent manner. The hypoglycemic effects of these compounds were more evident at 3 h and 5 h after administration of tested compounds which was similar to the effect displayed by the positive control. In addition, the binding energies calculated from the docking studies with the alpha-amylase enzyme (PDB ID: 1HNY) and biological activities indicate that the compounds containing nitro moiety on the phenyl group contributed significantly towards the antidiabetic activity.
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