An article Ruthenium(II)-Catalyzed Hydrogen Isotope Exchange of Pharmaceutical Drugs by C-H Deuteration and C-H Tritiation WOS:000500587200001 published article about CATALYZED H/D EXCHANGE; WEAK-COORDINATION; OXIDASE CATALYSIS; LABELED COMPOUNDS; N-HETEROCYCLES; ACTIVATION; DEUTERIUM; COMPLEXES; DISCOVERY; TRITIUM in [Mueller, Valentin; Ackermann, Lutz] Georg August Univ Gottingen, Inst Organ & Biomol Chem, Tammannstr 2, D-37077 Gottingen, Germany; [Weck, Remo; Derdau, Volker] Sanofi Aventis Deutschland GmbH, R&D, Integrated Drug Discovery, Isotope Chem, Ind Pk Hochst, D-65926 Frankfurt, Germany in 2020.0, Cited 105.0. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7. Name: 3-Methylbenzoic acid
Well-defined ruthenium(II) biscarboxylate complexes enabled selective ortho-deuteration with weakly-coordinating, synthetically useful carboxylic acid with outstanding levels of isotopic labeling. The robust nature of the catalytic system was reflected by a broad functional group tolerance in an operationally-simple manner, allowing the isotope labeling of challenging pharmaceuticals and bioactive heterocyclic motifs. The synthetic power of our method was highlighted by the selective tritium-labeling of repaglinide, an antidiabetic drug, providing access to defined tritium labeled therapeutics.
Name: 3-Methylbenzoic acid. Welcome to talk about 99-04-7, If you have any questions, you can contact Muller, V; Weck, R; Derdau, V; Ackermann, L or send Email.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com