Quality Control of 3-Methylbenzoic acid. Recently I am researching about NF-KAPPA-B; ALZHEIMERS-DISEASE; A-BETA; INHIBITION; RECEPTOR; GSK-3-BETA; APOPTOSIS; RAGE; TRANSLOCATION; DEGRADATION, Saw an article supported by the Inner Mongolia Natural Science Foundation [2008JQ01]; CAS Light ofWest China Program. Published in MDPI in BASEL ,Authors: Liu, Z; Bian, M; Ma, QQ; Zhang, Z; Du, HH; Wei, CX. The CAS is 99-04-7. Through research, I have a further understanding and discovery of 3-Methylbenzoic acid
A series of novel synthetic substituted benzo[d]oxazole-based derivatives (5a-5v) exerted neuroprotective effects on beta-amyloid (A beta)-induced PC12 cells as a potential approach for the treatment of Alzheimer’s disease (AD). In vitro studies show that most of the synthesized compounds were potent in reducing the neurotoxicity of A beta(25-35)-induced PC12 cells at 5 mu g/mL. We found that compound 5c was non-neurotoxic at 30 mu g/mL and significantly increased the viability of A beta(25-35)-induced PC12 cells at 1.25, 2.5 and 5 mu g/mL. Western blot analysis showed that compound 5c promoted the phosphorylation of Akt and glycogen synthase kinase (GSK-3 beta) and decreased the expression of nuclear factor-kappa B (NF-kappa B) in A beta(25-35)-induced PC12 cells. In addition, our findings demonstrated that compound 5c protected PC12 cells from A beta(25-35)-induced apoptosis and reduced the hyperphosphorylation of tau protein, and decreased the expression of receptor for AGE (RAGE), beta-site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1), inducible nitric oxide synthase (iNOS) and Bcl-2-associated X protein/B-cell lymphoma 2 (Bax/Bcl-2) via Akt/GSK-3 beta/NF-kappa B signaling pathway. In vivo studies suggest that compound 5c shows less toxicity than donepezil in the heart and nervous system of zebrafish.
Quality Control of 3-Methylbenzoic acid. Welcome to talk about 99-04-7, If you have any questions, you can contact Liu, Z; Bian, M; Ma, QQ; Zhang, Z; Du, HH; Wei, CX or send Email.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com