Isothiazole-4-carboxylic acid, cas is 822-82-2, it is a common heterocyclic compound, the isothiazole compound, its synthesis route is as follows.,822-82-2
To a solution of isothiazole-4-carboxylic acid (1.70 g, 12.98 mmol) in THF (17 ml) was added t-BuLi (29.95 mL) at -78 C, and then a solution of CBr4 (8.62 g, 25.96 mmol) in THF (10 ml) was added dropwise. The mixture was stirred at -78 C for 2 h, quenched with addition of saturated aqueous NH4Cl and extracted with EtOAc (50 mL x 3). The aqueous layer was adjusted to pH ~1.5 by addition of HCl, and then extracted with EtOAc (50 mL x 3). The combined organic layers were dried over MgSO4, filtered, and concentrated in vacuo providing the title compound (1.50 g), which was used without further purification.
822-82-2 is used more and more widely, we look forward to future research findings about Isothiazole-4-carboxylic acid
Reference£º
Patent; MERCK SHARP & DOHME CORP.; LIVERTON, Nigel; BESHORE, Douglas, C.; KUDUK, Scott, D.; LUO, Yunfu; MENG, Na; YU, Tingting; WO2015/20930; (2015); A1;,
Isothiazole – Wikipedia
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