Safety of 3-Methylbenzoic acid. Recently I am researching about NOD1 VARIATION; IDENTIFICATION; ASSOCIATION; DOMAIN; SUSCEPTIBILITY; PEPTIDOGLYCAN; ACTIVATION; BINDING, Saw an article supported by the . Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Haffner, CD; Charnley, AK; Aquino, CJ; Casillas, L; Convery, MA; Cox, JA; Elban, MA; Goodwin, NC; Gough, PJ; Haile, PA; Hughes, TV; Knapp-Reed, B; Kreatsoulas, C; Lakdawala, AS; Li, HJ; Lian, YQ; Lipshutz, D; Mehlmann, JF; Ouellette, M; Romano, J; Shewchuk, L; Shu, A; Votta, BJ; Zhou, HQ; Bertin, J; Marquis, RW. The CAS is 99-04-7. Through research, I have a further understanding and discovery of 3-Methylbenzoic acid
Herein we report the discovery of pyrazolocarboxamides as novel, potent, and kinase selective inhibitors of receptor interacting protein 2 kinase (RIP2). Fragment based screening and design principles led to the identification of the inhibitor series, and X-ray crystallography was used to inform key structural changes. Through key substitutions about the N1 and C5 N positions on the pyrazole ring significant kinase selectivity and potency were achieved. Bridged bicyclic pyrazolocarboxamide 11 represents a selective and potent inhibitor of RIP2 and will allow for a more detailed investigation of RIP2 inhibition as a therapeutic target for autoinflammatory disorders.
Welcome to talk about 99-04-7, If you have any questions, you can contact Haffner, CD; Charnley, AK; Aquino, CJ; Casillas, L; Convery, MA; Cox, JA; Elban, MA; Goodwin, NC; Gough, PJ; Haile, PA; Hughes, TV; Knapp-Reed, B; Kreatsoulas, C; Lakdawala, AS; Li, HJ; Lian, YQ; Lipshutz, D; Mehlmann, JF; Ouellette, M; Romano, J; Shewchuk, L; Shu, A; Votta, BJ; Zhou, HQ; Bertin, J; Marquis, RW or send Email.. Safety of 3-Methylbenzoic acid
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com