Category: isothiazole. Weis, E; Johansson, MJ; Martin-Matute, B in [Weis, Erik; Martin-Matute, Belen] Stockholm Univ, Dept Organ Chem, S-10691 Stockholm, Sweden; [Weis, Erik; Johansson, Magnus J.] AstraZeneca, Med Chem Res & Early Dev, Cardiovasc Renal & Metab CVRM, BioPharmaceut R&D, Gothenburg, Sweden published Ir-III-Catalyzed Selectiveortho-Monoiodination of Benzoic Acids with Unbiased C-H Bonds in 2020, Cited 57. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7.
An iridium-catalyzed selectiveortho-monoiodination of benzoic acids with two equivalent C-H bonds is presented. A wide range of electron-rich and electron-poor substrates undergo the reaction under mild conditions, with >20:1 mono/di selectivity. Importantly, the C-H iodination occurs selectivelyorthoto the carboxylic acid moiety in substrates bearing competing coordinating directing groups. The reaction is performed at room temperature and no inert atmosphere or exclusion of moisture is required. Mechanistic investigations revealed a substrate-dependent reversible C-H activation/protodemetalation step, a substrate-dependent turnover-limiting step, and the crucial role of the Ag(I)additive in the deactivation of the iodination product towards further reaction.
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Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com