822-82-2, Isothiazole-4-carboxylic acid is a isothiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of isothiazole-4-carboxylic acid (1.70 g, 12.98 mmol) in THF (17 ml) was added t-BuLi (29.95 mL) at -78 C, and then a solution of CBr4 (8.62 g, 25.96 mmol) in THF (10 ml) was added dropwise. The mixture was stirred at -78 C for 2 h, quenched with addition of saturated aqueous NH4Cl and extracted with EtOAc (50 mL x 3). The aqueous layer was adjusted to pH ~1.5 by addition of HCl, and then extracted with EtOAc (50 mL x 3). The combined organic layers were dried over MgSO4, filtered, and concentrated in vacuo providing the title compound (1.50 g), which was used without further purification.
As the paragraph descriping shows that 822-82-2 is playing an increasingly important role.
Reference£º
Patent; MERCK SHARP & DOHME CORP.; LIVERTON, Nigel; BESHORE, Douglas, C.; KUDUK, Scott, D.; LUO, Yunfu; MENG, Na; YU, Tingting; WO2015/20930; (2015); A1;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com