Safety of 2,5-Dimethoxybenzaldehyde. In 2019.0 BIOORGAN MED CHEM published article about AMYLOID-BETA; DISEASE; BUTYRYLCHOLINESTERASE; ACETYLCHOLINESTERASE; ANTIOXIDANT; PROTOCOL; DOCKING; IDENTIFICATION; ABSORPTION; TARGETS in [Umar, Tarana; Hoda, Nasimul] Cent Univ, Jamia Millia Islamia, Dept Chem, New Delhi 110025, India; [Gusain, Siddharth; Shalini, Shruti; Tiwari, Manisha] Univ Delhi, Dr BR Ambedkar Ctr Biomed Res, New Delhi 110007, India; [Raza, Md Kausar] Indian Inst Sci, Dept Inorgan & Phys Chem, Bangalore 560012, Karnataka, India; [Kumar, Jitendra] Sardar Vallabhbhai Patel Coll, Dept Chem, Bhabua 821101, Kaimur, India; [Kumar, Jitendra] VKSU, Ara 802301, Bihar, India in 2019.0, Cited 38.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7.
In an attempt to construct potential anti-Alzheimer’s agents Naphthalene-triazolopyrimidine hybrids were synthesized and screened in vitro against the two cholinesterases (ChE) s, amyloid beta aggregation and for antioxidation activity. Single-crystal X-ray crystallography was utilized for crystal structure determination of one of the compounds. In vitro study of compounds revealed that most of the compounds are capable of inhibiting acetylcholinesterase and Butyrylcholinesterase activity. Particularly, the compounds 4e and 4d exhibited IC50 values ranging from 8.6 to 14 nM against AChE lower than the standard drug Donepezil (IC50 49 nM). Best result was found for compound 4e with IC50 of 8.6 nM (for AChE) and 150 nM (for BuChE). Selectivity upto that of Donepezil and even more was observed for 4a, 4c and 4h. Investigation by electron microscopy, transmission electron microscopy and ThT fluorescence assay unveils the fact that synthesized hybrids exhibit amyloid beta self-aggregation inhibition. The compounds 4i and 4j revealed highest inhibitory potential, 85.46% and 72.77% at 50 mu M respectively; above the standard A beta disaggregating agent, Curcumin. Their antioxidation profile was also analyzed. Studies from DPPH free radical scavenging assay and ORAC assay depicts molecules to possess low antioxidation profile. Results suggest that triazolopyrimidines are potential candidate for Acetylcholinesterase (AChE), Butyrylcholinesterase (BuChE), and amyloid beta aggregation inhibition. In silico ADMET profiling indicates drug-like properties with a very low toxic influence. Such synthesized compounds provide a strong vision for further development of potential anti-Alzheimer’s agents.
Safety of 2,5-Dimethoxybenzaldehyde. Welcome to talk about 93-02-7, If you have any questions, you can contact Umar, T; Gusain, S; Raza, MK; Shalini, S; Kumar, J; Tiwari, M; Hoda, N or send Email.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com