In 2019 J MOL STRUCT published article about PROSTAGLANDIN E-2 BIOSYNTHESIS; DIARYLPENTANOID ANALOGS; NITRIC-OXIDE; BIOLOGICAL EVALUATION; CRYSTAL-STRUCTURE; IDENTIFICATION; SIMULATIONS; ANTIOXIDANT; DOCKING; MURINE in [Aluwi, Mohd Fadhlizil Fasihi Mohd] Univ Malaysia Pahang, Fac Ind Sci & Technol, Gambang 26300, Pahang, Malaysia; [Rullah, Kamal] Int Islamic Univ Malaysia, Dept Pharmaceut Chem, Kuliyyah Pharm, Kuantan 25200, Pahang, Malaysia; [Koeberle, Andreas; Werz, Oliver] Friedrich Schiller Univ Jena, Inst Pharm, Dept Pharmaceut Med Chem, D-07743 Jena, Germany; [Razak, Nur Sakinah Abdul; Wai, Lam Kok] Univ Kebangsaan Malaysia, Fac Pharm, Drug & Herbal Res Ctr, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, Malaysia; [Wei, Leong Sze] Univ Putra Malaysia, Fac Biotechnol & Biomol Sci, Dept Microbiol, Serdang 43400, Selangor, Malaysia; [Salim, Fatimah; Ismail, Nor Hadiani] Univ Teknol MARA, Atta Ur Rahman Inst Nat Prod Discovery, Kampus Puncak Alam, Puncak Alam 42300, Selangor, Malaysia; [Jantan, Ibrahim] Taylor Univ, Sch Pharm, Lakeside Campus,1 Jalan Taylor, Subang Jaya 47500, Selangor Darul, Malaysia in 2019, Cited 25. The Name is Benzoic anhydride. Through research, I have a further understanding and discovery of 93-97-0. Recommanded Product: 93-97-0
The search of novel mPGES-1 inhibitors has recently intensified probably due to the superior safety in comparison to existing anti-inflammatory drugs. Although two mPGES-1 inhibitors have entered clinical trials, none has yet reached the market. In this study, we performed modifications guided by 3D-QSAR CoMFA on 2, which is an unsymmetrical curcumin derivative with low binding affinity towards mPGES-1. To counter the PAINS properties predicted for 2, the diketone linker was replaced with a pyrazole ring. On the other hand, both prenyl and carboxylate ester groups were introduced to improve the activity. When tested in vitro, 11 suppressed PGE(2) biosynthesis in activated macrophages and showed promising human mPGES-1 inhibition in microsomes of interleukin-1 beta-stimulated A549 cells. Altogether, 11 has been identified as a potential mPGES-1 inhibitor and could be a promising lead for a novel class of mPGES-1 inhibitors. (C) 2019 Elsevier B.V. All rights reserved.
Recommanded Product: 93-97-0. Welcome to talk about 93-97-0, If you have any questions, you can contact Aluwi, MFFM; Rullah, K; Koeberle, A; Werz, O; Razak, NSA; Wei, LS; Salim, F; Ismail, NH; Jantan, I; Wai, LK or send Email.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com