In 2019.0 ACS CHEM NEUROSCI published article about POTENTIAL ANTICANCER AGENTS; BIOLOGICAL EVALUATION; PATHWAY ACTIVATION; OXIDATIVE STRESS; CURCUMIN; PIPLARTINE; MECHANISMS; INHIBITORS; DISCOVERY; OCCLUSION in [Li, Ge; Zheng, Yuantie; Yao, Jiali; Hu, Linya; Liu, Qunpeng; Ke, Furong; Feng, Weixiao; Zhao, Ya; Yan, Pencheng; He, Wenfei; Qiu, Peihong; Wu, Jianzhang] Wenzhou Med Univ, Sch Pharmaceut Sci, Chem Biol Res Ctr, Wenzhou 325035, Zhejiang, Peoples R China; [Feng, Weixiao; Li, Wulan] Wenzhou Med Univ, Affiliated Hosp 1, Wenzhou 325035, Zhejiang, Peoples R China; [Zhao, Ya; Deng, Hui] Wenzhou Med Univ, Dept Periodont, Hosp & Sch Stomatol, 373 West Xueyuan Rd, Wenzhou 325035, Zhejiang, Peoples R China; [Liu, Qunpeng] Wenzhou Univ, Coll Chem & Mat Engn, Wenzhou 325035, Zhejiang, Peoples R China in 2019.0, Cited 50.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7. Product Details of 93-02-7
The supplementation of exogenous antioxidants to scavenge excessive reactive oxygen species (ROS) is an effective treatment for cerebral ischemia-reperfusion injury (CIRI) in stroke. Piperlongumine (PL), a natural alkaloid, has a great potential as a neuroprotective agent, but it also has obvious toxicity. Moreover, its neuroprotective effects remain to be improved. In this study, we designed a series of novel PL analogs by hybridizing the screened low-toxicity diketene skeleton with antioxidant effect and the 3,4,5-trimethoxyphenyl group, which may increase the antioxidant activity of PL. The intermediate was synthesized by a novel green synthesis method, and 34 compounds were obtained. The compounds without obvious cytotoxicity have remarkable antioxidant effects, especially compared with diketene skeletons and PL. The cytoprotection of the active compound decreased significantly by reduction of the carbon-carbon double bonds of the Michael acceptor in the diketene skeleton. More importantly, further study revealed that compound A9, which has the best activity, can confer protection for cells against oxidative stress and attenuate brain injury in vivo. Overall, this study provided a promising drug candidate for the treatment of CIRI and guided the further development of drug research in oxidative stress-mediated diseases.
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Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com