Name is 3-Chlorobenzo[d]isothiazole, as a common heterocyclic compound, it belongs to isothiazole compound, and cas is 7716-66-7, its synthesis route is as follows.,7716-66-7
Ethylenediamine (45 mL) was heated to 80 0C. A room temperature solution of 3-chlorobenzo[d]isothiazole (12g, 70.7 mmol) in ethylenediamine (5 mL) was added to the heated ethylenediamine dropwise. The resulting solution was heated at 80 0C for 3 h. The reaction mixture was cooled to room temperature and water (75 mL) was added. The aqueous mixture was extracted with ethyl acetate twice and the ethyl acetate layers were separated. The combined organic layers were dried over anhydrous sodium sulfate, filtered and the filtrate concentrated under reduced pressure to yield N1-(benzo[d]isothiazol-3-yl)ethane-l,2-diamine as a light yellow solid (8 g). 1H-NMR (300 MHz, CDCl3): 7.79-7.64 (m, 2H), 7.52 (t, IH), 7.34 (t, IH), 5.60 (broad s, IH), 3.62 (t, 2H), 3.08 ppm (t, 2H).
With the complex challenges of chemical substances, we look forward to future research findings about 3-Chlorobenzo[d]isothiazole
Reference£º
Patent; RIGEL PHARMACEUTICALS, INC.; WO2006/91858; (2006); A1;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com