I found the field of Chemistry very interesting. Saw the article Enantioselective Synthesis of Atropisomeric Biaryls using Biaryl 2,5-Diphenylphospholanes as Ligands for Palladium-Catalysed Suzuki-Miyaura Reactions published in 2021. Product Details of 151-10-0, Reprint Addresses Byrne, L; Smith, PD (corresponding author), AstraZeneca, Early Chem Dev, R&D, Pharmaceut Sci, Macclesfield, Cheshire, England.. The CAS is 151-10-0. Through research, I have a further understanding and discovery of 1,3-Dimethoxybenzene
Here we describe the development of biaryl 2,5-diphenylphospholanes as a new class of C-2-symmetric, monodentate ligands for asymmetric Suzuki-Miyaura (ASM) reactions. Screening of a series of exemplary phospholanes led to the identification of two ligands that were used to prepare a range of atropisomeric biaryl and heterobiaryl products with good to excellent levels of enantioselectivity (up to 97:3 e.r.) under mild conditions. DFT studies suggest that the formation of a constraining ligand pocket and coordination of one of the biaryl methoxy groups in the optimised ligands to the metal centre is crucial for restricting conformational freedom in the bond-forming step.
About 1,3-Dimethoxybenzene, If you have any questions, you can contact Byrne, L; Skold, C; Norrby, PO; Munday, RH; Turner, AR; Smith, PD or concate me.. Product Details of 151-10-0
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com