Authors Hernandez, C; Moreno, G; Herrera, A; Cardona, W in MDPI published article about BIOLOGICAL EVALUATION; ANTICANCER ACTIVITY; DERIVATIVES; DESIGN; PROLIFERATION; MECHANISMS; APOPTOSIS; EFFICIENT in [Hernandez, Cristian; Moreno, Gustavo; Herrera-R, Angie; Cardona-G, Wilson] Univ Antioquia UdeA, Inst Chem, Fac Exact & Nat Sci, Quim Plantas Colombianas, Calle 70 52-21, Medellin 1226, Colombia in 2021, Cited 46. Recommanded Product: 93-02-7. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7
We synthesized twelve hybrids based on curcumin and resveratrol, and their structures were elucidated by spectroscopic analysis. The chemopreventive potential of these compounds was evaluated against SW480 human colon adenocarcinoma cells, its metastatic derivative SW620, along with the non-malignant CHO-K1 cell line. Among the tested compounds, hybrids 3e and 3i (for SW480) and 3a, 3e and 3k (for SW620) displayed the best cytotoxic activity with IC50 values ranging from 11.52 +/- 2.78 to 29.33 +/- 4.73 mu M for both cell lines, with selectivity indices (SI) higher than 1, after 48 h of treatment. Selectivity indices were even higher than those reported for the reference drug, 5-fluorouracil (SI = 0.96), the starting compound resveratrol (SI = 0.45) and the equimolar mixture of curcumin plus resveratrol (SI = 0.77). The previous hybrids showed good antiproliferative activity.
Recommanded Product: 93-02-7. Welcome to talk about 93-02-7, If you have any questions, you can contact Hernandez, C; Moreno, G; Herrera, A; Cardona, W or send Email.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com