An article Novel 1,3,4-thiadiazole conjugates derived from protocatechuic acid: Synthesis, antioxidant activity, and computational and electrochemical studies WOS:000525392600005 published article about OXIDATIVE STRESS; HYDROGEN-PEROXIDE; RADICAL-CATION; VITAMIN-E; MECHANISMS; ATOM; DERIVATIVES; INHIBITION; MANAGEMENT; REDUCTION in [Jakovljevic, Katarina; Joksovic, Milan D.; Avdovic, Edina; Mihailovic, Vladimir; Andric, Marijana; Markovic, Violeta] Univ Kragujevac, Fac Sci, Dept Chem, R Domanovica 12, Kragujevac 34000, Serbia; [Botta, Bruno] Sapienza Univ Roma, Dipartimento Chim & Tecnol Farmaco, Ple Aldo Moro 5, I-00185 Rome, Italy; [Jovanovic, Ljiljana S.] Univ Novi Sad, Fac Sci, Trg D Obradovica 3, Novi Sad 21000, Serbia; [Markovic, Zoran] State Univ Novi Pazar, Dept ChemicalTechnol Sci, Novi Pazar 36300, Serbia; [Trifunovic, Snezana] Univ Belgrade, Fac Chem, Studentski Trg 16, Belgrade 11000, Serbia in 2019, Cited 55. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7. Application In Synthesis of 3-Methylbenzoic acid
A series of 15 novel 1,3,4-thiadiazole amide derivatives containing a protocatechuic acid moiety were synthesized and structurally characterized. In addition, the corresponding imino (4) and amino (5) analogues of a phenyl-substituted 1,3,4-thiadiazole amide derivative 3a were prepared to compare the effects of the structural changes on the radical-scavenging activity. The obtained compounds were examined for their antioxidative potential by 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assays. In addition, selected compounds were studied by density functional theory (DFT) and cyclic voltammetry experiments. The tested compounds showed high potential to scavenging DPPH radical and ABTS radical cation compared with the referent antioxidants ascorbic acid and nordihydroguaiaretic acid (NDGA). On the basis of the calculated thermodynamic parameters, it can be concluded that the sequential proton loss electron transfer (SPLET) mechanism represents the most probable reaction path in a polar solvent for DPPH radical-scavenging activity. On the other hand, the single electron transfer followed by proton transfer (SET-PT) can be a likely mechanistic pathway in the case of an ABTS radical cation. (C) 2019 Academie des sciences. Published by Elsevier Masson SAS. All rights reserved.
Application In Synthesis of 3-Methylbenzoic acid. Welcome to talk about 99-04-7, If you have any questions, you can contact Jakovljevic, K; Joksovic, MD; Botta, B; Jovanovic, LS; Avdovic, E; Markovic, Z; Mihailovic, V; Andric, M; Trifunovic, S; Markovic, V or send Email.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com