COA of Formula: C14H10O3. Recently I am researching about VON-WILLEBRAND-FACTOR; PLATELET ACTIVATION; PREVENTS THROMBOSIS; LACTIC-ACIDOSIS; METFORMIN; RISK; ADHESION; PRODRUG, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81673710, 81973580]; National Major Scientific and Technological Special Project for Significant New Drugs Development [2019ZX09201005-005-001, 2019ZX09201005-005-004]; Applied Basic Research Programs of Department of Science and Technology of Sichuan Province [2019YJ0095]; National Science Foundation for Young Scientists of China [81803866]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2018M640932, 2019T120854]; Innovative Chinese Medicine and Health Products Research Academician Workstation of Academician Zhang Boli and Academician Zhu Beiwei, West China Hospital, Sichuan University [HXYS19001, HXYS19002]; Postdoctoral Interdisciplinary Research Project of Sichuan University [2019JCXK3245]; Post-Doctor Research Project, West China Hospital, Sichuan University [2018HXBH061, 2019HXBH024]; Sichuan Science and Technology Department Emergency Project for COVID-19 [2020YFS0554]. Published in ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER in ISSY-LES-MOULINEAUX ,Authors: Xin, G; Ming, Y; Ji, CJ; Wei, ZL; Li, SY; Morris-Natschke, SL; Zhang, XY; Yu, K; Li, YP; Zhang, BL; Zhang, JH; Xing, ZH; He, YR; Chen, Z; Yang, XJ; Niu, H; Lee, KH; Huang, W. The CAS is 93-97-0. Through research, I have a further understanding and discovery of Benzoic anhydride
Platelet thrombosis is the main pathogeny resulting in the low curability of ischemic stroke, a leading cause of mortality and disability worldwide. Metformin, a biguanide derivative that is the first-line oral medicine for type 2 diabetes, alleviates the severity of ischemic stroke in diabetic patients and suppresses platelet activation in experimental animal model. However, the clinical implementation of commercial biguanide analogs for stroke related to platelet thrombosis remains challenging due to its weak potency, poor pharmacokinetic characteristics and possible hypoglycemia. Here, twenty-three biguanide derivatives were designed and synthesized based on the principles of bioisosteres. These derivatives were evaluated for the activity of antiplatelet thrombosis in vivo. We found that N-tri-fluoromethanesulfonyl biguanide derivative, compound b10, uniquely prevented cerebral infarction as well as neuronal function injury, and significantly decrease the mortality rate of ischemic stroke in the middle cerebral artery occlusion mice without significant side effects. We verified that b10 directly inhibited platelets thrombus formation and decreased the compactness of stroke thrombi. Particularly, b10 exhibited good potency to inhibit human platelet activation including platelet aggregation, adhesion, pseudopodia formation, integrin GPIIb/IIIa activation, CD62P expression and clot retraction. Meanwhile, the pharmacokinetics assessment showed that b10 had satisfying pharmacological characteristics including a longer duration and a higher oral absorption ratio than its parent compound. In addition, b10 remarkably ameliorated not only stroke related to platelet thrombosis but also carotid artery thrombus formation. It is concluded that the novel potent antiplatelet thrombotic agent derived from biguanide is a promising candidate for stroke treatment. (C) 2020 Elsevier Masson SAS. All rights reserved.
COA of Formula: C14H10O3. About Benzoic anhydride, If you have any questions, you can contact Xin, G; Ming, Y; Ji, CJ; Wei, ZL; Li, SY; Morris-Natschke, SL; Zhang, XY; Yu, K; Li, YP; Zhang, BL; Zhang, JH; Xing, ZH; He, YR; Chen, Z; Yang, XJ; Niu, H; Lee, KH; Huang, W or concate me.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com