Name is Isothiazole-4-carboxylic acid, as a common heterocyclic compound, it belongs to isothiazole compound, and cas is 822-82-2, its synthesis route is as follows.,822-82-2
To a solution of isothiazole-4-carboxylic acid (1. 70 g, 12.98 mmol) in THF (17ml) was added t-BuLi (29.95 mL) at -78 C, and then a solution of CBr4 (8.62 g, 25.96 mmol) in10 THF (10 ml) was added dropwise. The mixture was stirred at -78 oc for 2 h, quenched withaddition of saturated aqueous NH4Cl and extracted with EtOAc (50 mL x 3). The aqueous layerwas adjusted to pH~ 1.5 by addition ofHCl, and then extracted with EtOAc (50 mL x 3). Thecombined organic layers were dried over MgS04, filtered, and concentrated in vacuo providingthe title compound (1.50 g), which was used without further purification.
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Reference£º
Patent; MERCK SHARP & DOHME CORP.; BESHORE, Douglas C.; KUDUK, Scott D.; LIVERTON, Nigel; LUO, Yunfu; MENG, Na; YU, Tingting; WO2015/18029; (2015); A1;,
Isothiazole – Wikipedia
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