Isothiazole-5-carboxylic acid, cas is 10271-85-9, it is a common heterocyclic compound, the isothiazole compound, its synthesis route is as follows.,10271-85-9
To a solution of isothiazole-5-carboxylic acid (331 mg, 2.6 mmol) in DMF (21 ml) cooled to 0C was added HATU (1.0 g, 2.8 mmol) and after stirring for 30 minutes a solution ofIntermediate 7-d (1.0 g, 2.1 mmol) and DIPEA (1.1 ml, 6.4 mmol) in DMF (3 ml) was addeddropwise. The reaction was then stirred at room temperature for 1 day. A saturatedaqueous solution of ammonium chloride and ethyl acetate were then added, the organic layer was separated, washed with a saturated aqueous solution of NaHCO3 and brine, dried over anhydrous MgSO4, filtered and concentrated under reduced pressure. Purification by silica gel chromatography provided Intermediate 15-a as a beige solid.
10271-85-9 is used more and more widely, we look forward to future research findings about Isothiazole-5-carboxylic acid
Reference£º
Patent; PHARMASCIENCE INC.; LAURENT, Alain; ROSE, Yannick; MORRIS, Stephen J.; (181 pag.)WO2017/49401; (2017); A1;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com