In 2020 ORG LETT published article about C-H ACTIVATION; BENZOIC-ACIDS; REDUCTIVE ELIMINATION; TRIFLUOROETHYLATION; ANNULATION; FLUORINE; ARENES; PHARMACEUTICALS; CYCLIZATION; INDOLES in [Zhou, Kehan; Zhang, Jingyu] Soochow Univ, Coll Energy, Soochow Inst Energy & Mat Innovat, Suzhou 215006, Peoples R China; [Zhou, Kehan; Geng, Jingyao; Wang, Dongjie; Zhao, Yingsheng] Soochow Univ, Key Lab Organ Synth Jiangsu Prov, Coll Chem Chem Engn & Mat Sci, Suzhou 215123, Peoples R China in 2020, Cited 64. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7. Recommanded Product: 99-04-7
3-Bromo-1,1,1-trifluoroacetone was first disclosed as an effective indirect trifluoromethylation reagent to construct the important 3-trifluoromethyl isocoumarin skeleton. The reaction proceeds through a ligand-promoted, iridium-catalyzed ortho-selective C-H alkylation of benzoic acid and an intermolecular cyclization reaction promoted by silver acetate. A wide range of 3-trifluoromethyl isocoumarins can be easily obtained in moderate to good yields. Importantly, the isocoumarin skeleton can be easily formed in bioactive compounds, highlighting the importance of this reaction.
About 3-Methylbenzoic acid, If you have any questions, you can contact Zhou, KH; Geng, JY; Wang, DJ; Zhang, JY; Zhao, YS or concate me.. Recommanded Product: 99-04-7
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com