I found the field of Biochemistry & Molecular Biology; Chemistry very interesting. Saw the article Design, synthesis and photoinduced DNA cleavage studies of [1,2,4]-triazolo[4,3-a]quinoxalin-4(5H)-ones published in 2019.0. COA of Formula: C9H10O3, Reprint Addresses Sumran, G (corresponding author), DAV Coll Lahore, Dept Chem, Ambala City 134002, Haryana, India.. The CAS is 93-02-7. Through research, I have a further understanding and discovery of 2,5-Dimethoxybenzaldehyde
An expedient and eco-friendly synthesis of 1-aryl/heteroaryl-[1,2,4]-triazolo[4,3-a]quinoxalin-4(5H)-ones (4) has been accomplished via iodobenzene diacetate mediated oxidative intramolecular cyclization of 3-(2-(aryl/heteroarylidene)hydrazinyl)-quinoxalin-2(1H)-ones (3). Ten synthesized compounds 3 and 4 (10-40 mu g) on irradiation with UV light at lambda(max) 312 nm could lead to cleavage of supercoiled pMaxGFP DNA (Form I) into the relaxed DNA (Form II) without any additive. Further, DNA cleaving ability of triazoles was quantitatively evaluated and was found to be dependent on its structure, concentration, and strictly on photoirradiation time. Mechanistic investigations using several additives as potential inhibitors/activator revealed that the DNA photocleavage reaction involves Type-I pathway leading to formation of superoxide anion radicals (O-2(-center dot)) as the major reactive oxygen species responsible for photocleavage process.
COA of Formula: C9H10O3. About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Sumran, G; Aggarwal, R; Mittal, A; Aggarwal, A; Gupta, A or concate me.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com