Category: isothiazole. Gao, H; Lin, S; Zhang, SN; Chen, WJ; Liu, XW; Yang, G; Lerner, RA; Xu, HT; Zhou, Z; Yi, W in [Gao, Hui; Lin, Shuang; Chen, Weijie; Liu, Xiawen; Zhou, Zhi; Yi, Wei] Guangzhou Med Univ, Guangzhou Municipal & Guangdong Prov Key Lab Prot, State Key Lab Resp Dis, Sch Pharmaceut Sci, Guangzhou 511436, Guangdong, Peoples R China; [Gao, Hui; Lin, Shuang; Chen, Weijie; Liu, Xiawen; Zhou, Zhi; Yi, Wei] Guangzhou Med Univ, Affiliated Hosp 5, Guangzhou 511436, Guangdong, Peoples R China; [Zhang, Shuning; Yang, Guang; Xu, Hongtao] ShanghaiTech Univ, Shanghai Inst Adv Immunochem Studies, Shanghai 201210, Peoples R China; [Zhang, Shuning; Yang, Guang; Xu, Hongtao] ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China; [Lerner, Richard A.] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA published gem-Difluoromethylene Alkyne-Enabled Diverse C-H Functionalization and Application to the on-DNA Synthesis of Difluorinated Isocoumarins in 2021.0, Cited 107.0. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7.
Using gem-difluoromethylene alkynes as effectors, unprecedented diverse C-H activation/[4+2] annulations of simple benzoic acids are reported. The chemodivergent reaction outcomes are well-tuned by Rh/Ir-catalyzed system; in the Rh-III catalysis, 3-alkenyl-1H-isochromen-1-one and 3,4-dialkylideneisochroman-1-one skeletons are afforded in a solvent-dependent manner whereas difluoromethylene-substituted 1H-isochromen-1-ones are generated under the Ir-III-catalyzed system. Mechanistic studies revealed that unusually double beta-F eliminations and fluorine effect-induced regioselective reductive elimination are independently involved to enable distinct reaction modes for divergent product formations. Besides, synthetic application in both the derivatization of obtained diene products and the on-DNA synthesis of DNA-tagged difluorinated isocoumarin have been demonstrated, which manifested great potential for synthetic utility of the developed protocols.
About 3-Methylbenzoic acid, If you have any questions, you can contact Gao, H; Lin, S; Zhang, SN; Chen, WJ; Liu, XW; Yang, G; Lerner, RA; Xu, HT; Zhou, Z; Yi, W or concate me.. Category: isothiazole
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com