Gandhi, SA; Barot, VM; Patel, MC; Malek, TJ; Patel, UH in [Gandhi, Sahaj A.] Bhavans Shri IL Pandya Arts Sci & Smt JM Shah Com, Dakor 388225, Gujarat, India; [Barot, V. M.; Patel, M. C.] Smt SM Panchal Sci Coll, PG Ctr Chem, Talod 383215, Gujarat, India; [Malek, T. J.] Kadi Sarva Vishwavidhayalay Univ, LDRP Inst Technol & Res, Gandhinagar 382024, Gujarat, India; [Patel, U. H.] Sardar Patel Univ, Dept Phys, Vallabh Vidyanagar 388120, Gujarat, India published MOLECULAR DOCKING, PHARMACOPHORE MODELLING AND 3D QSAR ANALYSIS OF NOVEL CHALCONE DERIVATIVES in 2019.0, Cited 18.0. Category: isothiazole. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7.
Chalcone based structures have many interesting biological properties like anti-malarial, anticancer, antiviral, antibacterial, antifungal, anti-hyperglycaemic and photo-cytotoxicity activities. In this study, the novel chalcone derivatives (1a-11) have been synthesized and investigated for antimicrobial activities. The MIC results of antimicrobial activities reveal that one of the chalcone derivative (2-Br- and 4OCH(3)- group) against specific bacteria are quite significant. 3D QSAR, three dimensional quantitative structure activity is one of the most powerful technique which involves the quantitative relationship between the biological activity of a set of compounds and their three dimensional structural properties, using statistical correlation methods. Pharmacophore modelling and molecular docking play an important role in drug design. To elucidate the relationship between structures and its activity, field-based 3D QSAR analysis has been carried out of novel chalcone derivatives. Structural properties such as electrostatic, hydrophobic, aromatic, and hydrogen-bond donor and acceptor have been worked out for novel chalcone derivatives. To investigate the influence of drugstore, chalcone derivatives (1a-11) have docked with receptor 210K and results displayed the highest Gscore of ligand If (3-OCH2C6H5-4-OCH3- group).
About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Gandhi, SA; Barot, VM; Patel, MC; Malek, TJ; Patel, UH or concate me.. Category: isothiazole
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com