COA of Formula: C8H8O2. Bai, BF; Bi, FC; Qin, YH; Teng, YT; Ma, ST in [Bai, Bingfang; Bi, Fangchao; Qin, Yinhui; Teng, Yuetai; Ma, Shutao] Shandong Univ, Cheeloo Coll Med, Sch Pharmaceut Sci, Dept Med Chem,Key Lab Chem Biol,Minist Educ, 44 West Wenhua Rd, Jinan 250012, Peoples R China published Design, synthesis and antibacterial evaluation of novel C-11, C-9 or C-2 ‘-substituted 3-O-descladinosyl-3-ketoclarithromycin derivatives in 2021, Cited 35. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7.
A novel series of 3-O-descladinosyl-3-keto-clarithromycin derivatives, including 11-O-carbamoyl-3-O-descladinosyl-3-keto-clarithromycin derivatives and 2 ‘,9(S)-diaryl-3-O-descladinosyl-3-keto-clarithromycin derivatives, were designed, synthesized and evaluated for their in vitro antibacterial activity. Among them, some derivatives were found to have activity against resistant bacteria strains. In particular, compound 9b showed not only the most significantly improved activity (16 mu g/mL) against S. aureus ATCC43300 and S. aureus ATCC31007, which was >16-fold more active than that of CAM and AZM, but also the best activity against S. pneumoniae B1 and S. pyogenes R1, with MIC values of 32 and 32 mu g/mL. In addition, compounds 9a, 9c, 9d and 9g exhibited the most effective activity against S. pneumoniae AB11 with MIC values of 32 or 64 mu g/mL as well. Unfortunately, 2 ‘,9 (S)-diaryl-3-O-descladinosyl-3-keto-clarithromycin derivatives failed to exhibit better antibacterial activity than references. It can be seen that the combined modification of the C-3 and C-11 positions of clarithromycin is beneficial to improve activity against resistant bacteria, while the single modification of the C-2 ” position is very detrimental to antibacterial activity.
COA of Formula: C8H8O2. About 3-Methylbenzoic acid, If you have any questions, you can contact Bai, BF; Bi, FC; Qin, YH; Teng, YT; Ma, ST or concate me.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com