3,4-Dichloroisothiazole-5-carboxylic acid, cas is 18480-53-0, it is a common heterocyclic compound, the isothiazole compound, its synthesis route is as follows.,18480-53-0
In a 250 ml single-mouth round bottom flask, 7.8 g of 3,4-dichloroisothiazole-5-carboxylic acid and 50 ml of thionyl chloride were added.The NaOH lye was inserted above the return pipe to absorb volatile thionyl chloride and refluxed at 80¡ãC for 5 hours.The solution turns light yellowRemove unreacted thionyl chloride by atmospheric pressure at 74¡ãC,Then vacuum distillation to collect 128 ¡ãCThe fraction yielded 5.9 g of colorless 3,4-dichloroisothiazole-5-formyl chloride,Using the resulting pure product to calculate the yield,Yield 69.3percent;
With the synthetic route has been constantly updated, we look forward to future research findings about 3,4-Dichloroisothiazole-5-carboxylic acid,belong isothiazole compound
Reference£º
Patent; Nankai University; Fan Zhijin; Zong Guangning; Ma Liuyong; Li Fengyun; Zhu Yujie; Chen Lai; Wang Haixia; Qian Xiaolin; Guo Xiaofeng; Pei Yu; Xu Jinghua; (21 pag.)CN104974150; (2018); B;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com