An article Ligand-Promoted Non-Directed C-H Cyanation of Arenes WOS:000461084900011 published article about PALLADIUM-CATALYZED CYANATION; TRANSITION-METAL; ARYL HALIDES; BOND ACTIVATION in [Liu, Luo-Yan; Yu, Jin-Quan] Scripps Res Inst, Dept Chem, 10550 North Torrey Pines Rd, La Jolla, CA 92037 USA; [Yeung, Kap-Sun] Bristol Myers Squibb Res & Dev, Discovery Chem, 5 Res Pkwy, Wallingford, CT 06492 USA in 2019, Cited 33. HPLC of Formula: C8H10O2. The Name is 1,3-Dimethoxybenzene. Through research, I have a further understanding and discovery of 151-10-0
This article reports the first example of a 2-pyridone accelerated non-directed C-H cyanation with an arene as the limiting reagent. This protocol is compatible with a broad scope of arenes, including advanced intermediates, drug molecules, and natural products. A kinetic isotope experiment (k(H)/k(D) =4.40) indicates that the C-H bond cleavage is the rate-limiting step. Also, the reaction is readily scalable, further showcasing the synthetic utility of this method.
HPLC of Formula: C8H10O2. About 1,3-Dimethoxybenzene, If you have any questions, you can contact Liu, LY; Yeung, KS; Yu, JQ or concate me.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com