Safety of 1,3-Dimethoxybenzene. I found the field of Chemistry very interesting. Saw the article Preparation of Functionalized Aryl, Heteroaryl, and Benzylic Potassium Organometallics Using Potassium Diisopropylamide in Continuous Flow published in 2020, Reprint Addresses Knochel, P (corresponding author), Ludwig Maximilians Univ Munchen, Dept Chem, Butenandtstr 5-13,Haus F, D-81377 Munich, Germany.. The CAS is 151-10-0. Through research, I have a further understanding and discovery of 1,3-Dimethoxybenzene.
We report the preparation of lithium-salt-free KDA (potassium diisopropylamide; 0.6 m in hexane) complexed with TMEDA (N,N,N ‘,N ‘-tetramethylethylenediamine) and its use for the flow-metalation of (hetero)arenes between -78 degrees C and 25 degrees C with reaction times between 0.2 s and 24 s and a combined flow rate of 10 mL min(-1) using a commercial flow setup. The resulting potassium organometallics react instantaneously with various electrophiles, such as ketones, aldehydes, alkyl and allylic halides, disulfides, Weinreb amides, and Me3SiCl, affording functionalized (hetero)arenes in high yields. This flow procedure is successfully extended to the lateral metalation of methyl-substituted arenes and heteroaromatics, resulting in the formation of various benzylic potassium organometallics. A metalation scale-up was possible without further optimization.
Safety of 1,3-Dimethoxybenzene. About 1,3-Dimethoxybenzene, If you have any questions, you can contact Harenberg, JH; Weidmann, N; Knochel, P or concate me.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com