Recently I am researching about MEDIATED DIECKMANN CYCLIZATION; HIGHLY SUBSTITUTED INDANONES; H BOND ALKENYLATIONS; ASYMMETRIC-SYNTHESIS; NAZAROV CYCLIZATION; CARBOXYLIC-ACIDS; ACRYLIC-ACIDS; BENZOIC-ACIDS; N BOND; EFFICIENT, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21776171, 21636006, 21572122]; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities [GK 201703019, GK 201601005]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Wang, JN; Chen, SQ; Liu, ZW; Shi, XY. The CAS is 99-04-7. Through research, I have a further understanding and discovery of 3-Methylbenzoic acid. Quality Control of 3-Methylbenzoic acid
The one-step strategy for the facile syntheses of structurally diverse 1-indanones in moderate to good isolated yields was developed via a ruthenium-catalyzed tandem coupling and cyclization of simple aromatic acids with alpha,beta-unsaturated ketones. The tandem cyclization involves one-pot sequential reactions of C-H activation, conjugate addition, Dieckmann condensation, Michael addition, intramolecular Aldol reaction, or hydrolysis. Switchable access to spiroindanones and 2-substituted 1-indanones could be achieved by manganese additive and H2O. Mn(II) additive is found to play an important role in this transformation, and a trace amount of water can promote the formation of 2-substituted 1-indanones. This process features the one-pot efficient construction of multiple C-C bonds, high step-economy, commercially available starting materials, and a broad substrate scope.
About 3-Methylbenzoic acid, If you have any questions, you can contact Wang, JN; Chen, SQ; Liu, ZW; Shi, XY or concate me.. Quality Control of 3-Methylbenzoic acid
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com