In 2020 CHEMMEDCHEM published article about CATALYZED SYNTHESIS; SIRTUIN INHIBITORS; IN-VITRO; ELECTROLUMINESCENCE; TRANSMISSION; ENTRY in [Hue, Bui Thi Buu; De, Tran Quang; Van Hieu, Mai; Van Tuan, Nguyen; Anh, Le Duc; Son, Nguyen Hoang; Duc Thanh, Danh La] Can Tho Univ, Coll Nat Sci, Dept Chem, Campus 2,3-2 St, Can Tho City, Vietnam; [Nguyen, Phuong Hong; Jo, Eunji; Thoa, Than Thi; Windisch, Marc P.] Inst Pasteur Korea, Appl Mol Virol Lab, Discovery Biol Div, Seongnam 13488, South Korea; [Nguyen, Phuong Hong; Windisch, Marc P.] Univ Sci & Technol, Div Biomed Sci & Technol, Daejeon 34141, South Korea; [Dupont-Rouzeyrol, Myrielle] Inst Pasteur Nouvelle Caledonie, URE Dengue & Arboviruses, Noumea 98800, New Caledonia; [Grailhe, Regis] Inst Pasteur Korea, Technol Dev Platform, Seongnam 13488, South Korea in 2020, Cited 42. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7. Safety of 2,5-Dimethoxybenzaldehyde
We have synthesized 50 benzimidazole (BMZ) derivatives with 1,2-phenylenediamines and aromatic aldehydes under mild oxidation conditions by using inexpensive, nontoxic inorganic salt sodium metabisulfite in a one-pot condensation reaction and screened their ability to interfere with Zika virus (ZIKV) infection utilizing a cell-based phenotypic assay. Seven BMZs inhibited an African ZIKV strain with a selectivity index (SI=CC50/EC50) of 9-37. Structure-activity relationship analysis demonstrated that substitution at the C-2, N-1, and C-5 positions of the BMZ ring were important for anti-ZIKV activity. The hybrid structure of BMZ and naphthalene rings was a structural feature responsible for the high anti-ZIKV activity. Importantly, BMZs inhibited ZIKV in human neural stem cells, a physiologically relevant system considering the severe congenital anomalies, like microcephaly, caused by ZIKV infection. Compound 39 displayed the highest antiviral efficacy against the African ZIKV strain in Huh-7 (SI>37) and neural stem cells (SI=12). Compound 35 possessed the highest activity in Vero cells (SI=115). Together, our data indicate that BMZs derivatives have to be considered for the development of ZIKV therapeutic interventions.
Safety of 2,5-Dimethoxybenzaldehyde. About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Hue, BTB; Nguyen, PH; De, TQ; Hieu, MV; Jo, E; Tuan, NV; Thoa, TT; Anh, L; Son, NH; Thanh, DLD; Dupont-Rouzeyrol, M; Grailhe, R; Windisch, MP or concate me.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com