An article A Focused DNA-Encoded Chemical Library for the Discovery of Inhibitors of NAD(+)-Dependent Enzymes WOS:000463843700021 published article about POLY(ADP-RIBOSE) POLYMERASE PARP; ADP-RIBOSYLTRANSFERASES; DEACETYLASE SIRT6; HIGHLY POTENT; CANCER-CELLS; SELECTION; DESIGN; PROTEIN; LIGANDS; IDENTIFICATION in [Yuen, Lik Hang; Dana, Srikanta; Franzini, Raphael M.] Univ Utah, Dept Med Chem, 30 S 2000 E, Salt Lake City, UT 84112 USA; [Thorsell, Ann-Gerd; Schuler, Herwig] Karolinska Inst, Dept Biosci & Nutr, Halsovagen 7c, S-14157 Huddinge, Sweden; [Neri, Dario] Swiss Fed Inst Technol, Dept Pharmaceut Sci, Vladimir Prelog Weg 3, CH-8093 Zurich, Switzerland; [Kireev, Dmitri] Univ N Carolina, UNC Eshelman Sch Pharm, Ctr Integrat Chem Biol & Drug Discovery, Chapel Hill, NC 27599 USA; [Liu, Yu; Bloom, Samuel I.; Donato, Anthony J.] Univ Utah, Dept Internal Med, 500 Foothill Dr, Salt Lake City, UT 84148 USA in 2019.0, Cited 98.0. SDS of cas: 99-04-7. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7
DNA-encoded chemical libraries are increasingly used in pharmaceutical research because they enable the rapid discovery of synthetic protein ligands. Here we explored whether target-class focused DNA-encoded chemical libraries can be cost-effective tools to achieve robust screening productivity for a series of proteins. The study revealed that a DNA-encoded library designed for NAD(+)-binding pockets (NADEL) effectively sampled the chemical binder space of enzymes with ADP-ribosyltransferase activity. The extracted information directed the synthesis of inhibitors for several enzymes including PARP15 and SIRT6. The high dissimilarity of NADEL screening fingerprints for different proteins translated into inhibitors that showed selectivity for their target. The discovery of patterns of enriched structures for six out of eight tested proteins is remarkable for a library of 58 302 DNA-tagged structures and illustrates the prospect of focused DNA-encoded libraries as economic alternatives to large library platforms.
About 3-Methylbenzoic acid, If you have any questions, you can contact Yuen, LH; Dana, S; Liu, Y; Bloom, SI; Thorsell, AG; Neri, D; Donato, AJ; Kireev, D; Schuler, H; Franzini, RM or concate me.. SDS of cas: 99-04-7
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