Recommanded Product: 2,6-Difluorobenzoic acid. Daley, RA; Morrenzin, AS; Neufeldt, SR; Topczewski, JJ in [Daley, Ryan A.; Topczewski, Joseph J.] Univ Minnesota Twin Cities, Dept Chem, Minneapolis, MN 55455 USA; [Morrenzin, Aaron S.; Neufeldt, Sharon R.] Montana State Univ, Dept Chem & Biochem, Bozeman, MT 59717 USA published Gold Catalyzed Decarboxylative Cross-Coupling of Iodoarenes in 2020, Cited 92. The Name is 2,6-Difluorobenzoic acid. Through research, I have a further understanding and discovery of 385-00-2.
This report details a decarboxylative cross-coupling of (hetero)aryl carboxylates with iodoarenes in the presence of a gold catalyst (>25 examples, up to 96% yield). This reaction is site specific, which overcomes prior limitations associated with gold catalyzed oxidative coupling reactions. The reactivity of the (hetero)aryl carboxylate correlates qualitatively to the field effect parameter (F-ortho). Reactions with isolated gold complexes and DFT calculations support a mechanism proceeding through oxidative addition at a gold(I) cation with decarboxylation being viable at either a gold(I) or a silver(I) species.
Recommanded Product: 2,6-Difluorobenzoic acid. About 2,6-Difluorobenzoic acid, If you have any questions, you can contact Daley, RA; Morrenzin, AS; Neufeldt, SR; Topczewski, JJ or concate me.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com