An article Rhodium(iii)-catalyzed synthesis of 3-trifluoromethylindanones from N-methoxybenzamides via C-H activation and Claisen/retro-Claisen reaction WOS:000542743600011 published article about SUPERELECTROPHILIC ACTIVATION; RH(III)-CATALYZED ANNULATION; EFFICIENT SYNTHESIS; CATALYZED SYNTHESIS; KETONES; BENZAMIDES; INDANONES; CONDENSATION; AMIDES; TRIFLUOROMETHYL in [Chaudhary, Bharatkumar; Kulkarni, Neeraj; Sharma, Satyasheel] Natl Inst Pharmaceut Educ & Res Ahmedabad NIPER A, Dept Med Chem, Gandhinagar 382355, Gujarat, India in 2020, Cited 74. Recommanded Product: 3-Methylbenzoic acid. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7
A rhodium(iii)-catalyzed reaction ofN-methoxybenzamides as a directing group with beta-trifluoromethyl-alpha,beta-unsaturated ketones is reported. The reaction involved sp(2)C-H activation, followed by the Claisen condensation involving a C-N bond cleavage to form 2-acyl-3-trifluoromethylindanone products. Furthermore, C2-unsubstituted 3-trifluoromethylindanone formation occurs through the trifluoroethanol-mediated retro-Claisen condensation reaction. This protocol is an efficient, straightforward route for the synthesis of 3-trifluoromethylindanone derivatives.
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