Formula: C7H4F2O2. In 2019 EUR J MED CHEM published article about DRUG SYNTHESIS BIODS in [Hameed, Shehryar; Kanwal; Seraj, Faiza; Rafique, Rafaila; Khan, Khalid Mohammed] Univ Karachi, Int Ctr Chem & Biol Sci, HEJ Res Inst Chem, Karachi 75270, Pakistan; [Chigurupati, Sridevi] Qassim Univ, Coll Pharm, Dept Med Chem & Pharmacognosy, Buraydah 52571, Saudi Arabia; [Wadood, Abdul; Rehman, Ashfaq Ur] Abdul Wali Khan Univ, Dept Biochem, Computat Med Chem Lab, UCSS, Mardan, Pakistan; [Venugopal, Vijayan] AIMST Univ, Fac Pharm, Bedong 08100, Kedah, Malaysia; [Salar, Uzma] Univ Karachi, Int Ctr Chem & Biol Sci, Dr Panjwani Ctr Mol Med & Drug Res, Karachi 75270, Pakistan; [Taha, Muhammad; Khan, Khalid Mohammed] Imam Abdulrahman Bin Faisal Univ, IRMC, Dept Clin Pharm, POB 1982, Dammam 31441, Saudi Arabia in 2019, Cited 29. The Name is 2,6-Difluorobenzoic acid. Through research, I have a further understanding and discovery of 385-00-2.
Benzotriazoles (4-6) were synthesized which were further reacted with different substituted benzoic acids and phenacyl bromides to synthesize benzotriazole derivatives (7-40). The synthetic compounds (7-40) were characterized via different spectroscopic techniques including EI-MS, HREI-MS, H-1-, and C-13 NMR. These molecules were examined for their anti-hyperglycemic potential hence were evaluated for alpha-glucosidase and alpha-amylase inhibitory activities. All benzotriazoles displayed moderate to good inhibitory activity in the range of IC50 values of 2.00-5.6 and 2.04-5.72 mu M against alpha-glucosidase and alpha-amylase enzymes, respectively. The synthetic compounds were divided into two categories A and B, in order to understand the structure-activity relationship. Compounds 25 (IC50 = 2.41 +/- 131 mu M), (IC50 = 2.5 +/- 1.21 mu M), 36 (IC50= 2.12 +/- 1.35 M), (IC50 = 2.21 +/- 1.08 mu M), and 37 (IC50 = 2.00 +/- 1.22 mu M), (IC50 = 2.04 +/- 1.4 mu M) with chloro substitution/s at aryl ring were found to be most active against alpha-glucosidase and alpha-amylase enzymes. Molecular docking studies on all compounds were performed which revealed that chloro substitutions are playing a pivotal role in the binding interactions. The enzyme inhibition mode was also studied and the kinetic studies revealed that the synthetic molecules have shown competitive mode of inhibition against alpha-amylase and non-competitive mode of inhibition against alpha-glucosidase enzyme. (C) 2019 Elsevier Masson SAS. All rights reserved.
Formula: C7H4F2O2. About 2,6-Difluorobenzoic acid, If you have any questions, you can contact Hameed, S; Kanwal; Seraj, F; Rafique, R; Chigurupati, S; Wadood, A; Rehman, AU; Venugopal, V; Salar, U; Taha, M; Khan, KM or concate me.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com