Product Details of 93-02-7. I found the field of Chemistry very interesting. Saw the article Design and Synthesis of New Tubulin Polymerization Inhibitors Inspired from Combretastatin A-4: An Anticancer Agent published in 2020.0, Reprint Addresses Holla, H (corresponding author), Cent Univ Karnataka, Dept Chem, Kalaburagi 585367, India.; Singh, S (corresponding author), Cent Univ Punjab, Dept Human Genet & Mol Med, Bathinda 151001, India.. The CAS is 93-02-7. Through research, I have a further understanding and discovery of 2,5-Dimethoxybenzaldehyde.
A series of 30 small hybrid molecules are synthesized inspired from Combretastatin A-4 (CA-4), where ethylene-bridge of CA-4 is replaced with two five-membered heterocyclic rings, viz. isoxazoline and 1, 2, 3-triazole. These are joined by a methylene linker, with substitutions at A and B – ring position of CA-4. The new molecular entities have shown significant cytotoxicity to cancer cell from the IC(50)0.49 mu M-3.17 mu M with 1-((4,5-Dihydro-3-(2,5-dimethoxyphenyl)isoxazol-5-yl)methyl)-4-(4-methoxyphenyl)-1H-1,2,3-triazole displayed IC(50)0.422 +/- 0.07 mu M for A-549 -lung cancer cell line and IC(50)0.498 +/- 0.03 mu M for MDA-MB-231-breast cancer cell line. The western blot analysis, confocal staining and also byin vitrotubulin polymerization assay established the target specificity of the molecules as a tubulin polymerization inhibitor. Molecular docking & Molecular dynamics studies confirmed the binding interaction patterns of these molecules at the Colchicine binding site of tubulin and have correlated the observed experimental result with variation in structure satisfactorily.
About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Sharma, A; Talimarada, D; Yadav, UP; Singh, N; Reddy, AS; Bag, D; Biswas, K; Baidya, A; Borale, AN; Shinde, D; Singh, S; Holla, H or concate me.. Product Details of 93-02-7
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com