3-Piperazinobenzisothiazole hydrochloride, cas is 87691-88-1, it is a common heterocyclic compound, the isothiazole compound, its synthesis route is as follows.,87691-88-1
EXAMPLE 133; 5-r2- (4-Benzordlisothiazol-3-vl-piperazin-1-vl)-ethvll-2, 3-dihvdro-indole-1- carboxylic acid tert-butvl ester; A mixture of 5-(2-chloro-ethyl)-2, 3-dihydro-indole-1-carboxylic acid ter-butyl ester (27.7 g, 0.098 mol), 3-piperazin-1-yl-benzo [aQisothiazole hydrochloride (20.2g, 0.079 mol) and sodium carbonate (18.6 g, 0.175 mol) in 1, 4-dioxane-water (320 + 560 mL) was stirred at reflux for 48 hours. Additional cesium carbonate (18 g, 0.055 mol) was added and the mixture was heated at reflux for an additional 6 hours. Mixture was cooled, diluted with water and extracted with ethyl acetate (2 x 1 L), dried and concentrated, purified via flash chromatography (heptane-ethyl acetate- triethyl amine/2: 1: 0.01) to provide a white powder. Yield : 26.2 g (67%). MS (APCI), (M+1) + = 465.2.
With the rapid development of chemical substances, we look forward to future research findings about 3-Piperazinobenzisothiazole hydrochloride
Reference£º
Patent; WARNER-LAMBERT COMPANY LLC; WO2005/66165; (2005); A1;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com