Reference of 114772-54-2, Researchers are common within chemical engineering and are often tasked with creating and developing new chemical techniques, frequently combining other advanced and emerging scientific areas. 114772-54-2, Name is 4′-(Bromomethyl)-[1,1′-biphenyl]-2-carbonitrile, SMILES is C1=CC=CC(=C1C2=CC=C(C=C2)CBr)C#N, belongs to isothiazole compound. In a article, author is Regiec, A., introduce new discover of the category.
The main goal of our study was the synthesis and biological evaluation of 4-amino- and 4-[(4-chlorobenzoyl)amino]-1-methylimidazole N-substituted 5-carboxamides. Biological in vitro tests indicated their remarkable influence on some cellular immune and inflammatory responses compared with ibuprofen and leflunomide as reference drugs. The toxicity of the tested compounds on murine bone marrow cells was also determined. The anti-inflammatory activity of 4-[(4-chlorobenzoyl)amino]-5-[N-(4-chlorophenyl)]-1-methyl-5-imidazolecarboxamide (7a) was confirmed in vivo in the carrageenan-induced oedema test. Comparison of the biological activity of 7a with that of the isosteric isothiazole derivative MR-2/94 suggests that replacement of the isothiazole core ring system with an imidazole one resulted in a considerable lowering of toxicity while maintaining anti-inflammatory and immunotropic properties.
Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield. If you are hungry for even more, make sure to check my other article about 114772-54-2, Reference of 114772-54-2.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com